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Safety Information

SML2783

Sigma-Aldrich

VU0409551

≥98% (HPLC)

Synonym(s):

JNJ 46778212, JNJ-46778212, VU 0409551, [6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)methanone

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5 MG
¥12,000
25 MG
¥48,200

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5 MG
¥12,000
25 MG
¥48,200

About This Item

Empirical Formula (Hill Notation):
C20H17FN2O3
CAS Number:
1363281-27-9
Molecular Weight:
352.36
MDL number:
MFCD29047143
UNSPSC Code:
12352200
NACRES:
NA.77

¥12,000

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N1CCC2=C(C1)OC(COC3=CC=CC=C3)=N2)C4=CC=C(C=C4)F

InChI key

QUZLMKNNIUSREV-UHFFFAOYSA-N

Biochem/physiol Actions

VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.
orally available, potent and selective biased mGlu5 PAM

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2783-VAR:
SML2783-5MG:
SML2783-25MG:
SML2783-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000358174
0000349351
0000349351
0000358174
0000243103

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Shane D Hellyer et al.
Journal of neurochemistry, 151(3), 301-315 (2019-08-04)
Allosteric modulators of metabotropic glutamate receptor 5 (mGlu5 ) are a promising therapeutic strategy for a number of neurological disorders. Multiple mGlu5 -positive allosteric modulator (PAM) chemotypes have been discovered that act as either pure PAMs or as PAM-agonists in
Jerri M Rook et al.
Neuron, 86(4), 1029-1040 (2015-05-06)
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate receptor subtype 5 (mGlu5) is a closely associated signaling partner with NMDARs and regulates NMDAR function in forebrain regions implicated in the pathology
Darrick T Balu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(8), 2052-2061 (2016-01-08)
There is substantial evidence that NMDA receptor (NMDAR) hypofunction contributes to the pathophysiology of schizophrenia (SCZ). A recent large-scale genome-wide association study identified serine racemase (SR), the enzyme that produces the NMDAR co-agonist D-serine, as a risk gene for SCZ.

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