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Safety Information

SML2636

Sigma-Aldrich

Sb4

≥98% (HPLC)

Synonym(s):

2-[[(4-Bromophenyl)methyl]thio]benzoxazole, BMP signaling agonist Sb4

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5 MG
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5 MG
¥13,350
25 MG
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About This Item

Empirical Formula (Hill Notation):
C14H10BrNOS
CAS Number:
100874-08-6
Molecular Weight:
320.20
MDL number:
MFCD01603921
UNSPSC Code:
12352200
NACRES:
NA.77

¥13,350

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC=C(CSC2=NC3=C(C=CC=C3)O2)C=C1

InChI

1S/C14H10BrNOS/c15-11-7-5-10(6-8-11)9-18-14-16-12-3-1-2-4-13(12)17-14/h1-8H,9H2

InChI key

JDVOIBFEFVKUPL-UHFFFAOYSA-N

Biochem/physiol Actions

Cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293)
Sb4 is a cell penetrant, potent bone morphogenetic protein (BMP) signaling agonist that rapidly activate BMP in human renal cells (HEK293). Sb4 activates BMP by stabilization of intracellular p-SMAD-1/5/9. Apparently activation of the BMP pathway by sb4 cannot be reversed by inhibition of Noggin or type I BMP kinase inhibitors

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2636-5MG:
SML2636-BULK:
SML2636-25MG:
SML2636-VAR:

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Shayna T J Bradford et al.
The Journal of biological chemistry, 294(9), 3125-3136 (2019-01-04)
Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to be protective by promoting renal repair and regeneration. Clinical use of recombinant BMPs

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