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Safety Information

SML2531

Sigma-Aldrich

TH5487

≥98% (HPLC)

Synonym(s):

4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C19H18BrIN4O2
CAS Number:
2304947-71-3
Molecular Weight:
541.18
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

IC1=CC=C(NC(N2CCC(N(C3=CC=CC(Br)=C3N4)C4=O)CC2)=O)C=C1

Biochem/physiol Actions

Inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)
TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG1-dependent proinflammatory gene expression by binding in the OGG1 active site, preventing OGG1 from engaging damaged DNA in vitro and in cells, resulting in decreased proinflammatory gene expression.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2531-5MG:
SML2531-BULK:
SML2531-25MG:
SML2531-VAR:

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Torkild Visnes et al.
Science (New York, N.Y.), 362(6416), 834-839 (2018-11-18)
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we

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