Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML2231

Sigma-Aldrich

Erasin

≥98% (HPLC)

Synonym(s):

(E)-N′-((6-(tert-butyl)-4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide, Erlotinib-resistance antagonizing STAT3 inhibitor

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥15,130
25 MG
¥61,030

¥15,130

Check Cart for Availability
All Photos(1)

Select a Size

Change View
5 MG
¥15,130
25 MG
¥61,030

About This Item

Empirical Formula (Hill Notation):
C20H19N3O3
CAS Number:
2256056-21-8
Molecular Weight:
349.38
UNSPSC Code:
12352200
NACRES:
NA.77

¥15,130

Check Cart for Availability

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(/C=N/NC(C2=CC=CN=C2)=O)=COC3=CC=C(C(C)(C)C)C=C31

InChI

1S/C20H19N3O3/c1-20(2,3)15-6-7-17-16(9-15)18(24)14(12-26-17)11-22-23-19(25)13-5-4-8-21-10-13/h4-12H,1-3H3,(H,23,25)/b22-11+

InChI key

JHUVYXUBEMYTNO-SSDVNMTOSA-N

Biochem/physiol Actions

Erasin (Erlotinib-resistance antagonizing STAT3 inhibitor) is a selective inhibitor of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. It was shown to increase the apoptotic rate of HCC-827 cells with acquired resistance against Erlotinib in addition to increasing the apoptotic rate of cultured NSCLC cells in a STAT3-dependent manner.
Selective inhibitor of STAT3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2231-BULK:
SML2231-25MG:
SML2231-5MG:
SML2231-VAR:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000051788
0000051787
0000040975

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Christian Lis et al.
Scientific reports, 7(1), 17390-17390 (2017-12-14)
Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications

Questions

  1. I need a list of the percentage of ingredients in ERASI for products going to Canada. Required by health canada for personal care products.

    1 answer

    1. Please see section 3 and section 15 of the Safety Data Sheet:
      https://www.sigmaaldrich.com/sds/sigma/sml2231.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service