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Safety Information

SML2123

Sigma-Aldrich

BRF110

≥98% (HPLC)

Synonym(s):

4-[Methyl[2-phenyl-5-(2-propen-1-yl)-6-(trifluoromethyl)-4-pyrimidinyl]amino]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C22H18F3N3O2
CAS Number:
2095489-35-1
Molecular Weight:
413.39
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=C(N(C2=NC(C3=CC=CC=C3)=NC(C(F)(F)F)=C2CC=C)C)C=C1)O

Biochem/physiol Actions

BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
brain penetrant, potent and selective agonist of Nurr1:RXRα heterodimer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2123-VAR:
SML2123-5MG:
SML2123-BULK:
SML2123-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000038462
0000038458
0000028833

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