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Safety Information

SML1677

Sigma-Aldrich

Tarocin A1

≥98% (HPLC)

Synonym(s):

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(isoquinolin-4-yl)propanoyl)-4-methyloxazolidin-2-one

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About This Item

Empirical Formula (Hill Notation):
C24H18F6N2O3
CAS Number:
Molecular Weight:
496.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

C[C@H](N1C(CCC2=C(C=CC=C3)C3=CN=C2)=O)[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OC1=O

InChI

1S/C24H18F6N2O3/c1-13-21(16-8-17(23(25,26)27)10-18(9-16)24(28,29)30)35-22(34)32(13)20(33)7-6-15-12-31-11-14-4-2-3-5-19(14)15/h2-5,8-13,21H,6-7H2,1H3/t13-,21-/m0/s1

InChI key

XWMRKUPNQVITEC-ZSEKCTLFSA-N

Biochem/physiol Actions

Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis.
Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis. Tarocin A1 has an IC50 value of 40 nM in a biochemical TarO assay. Tarocin A does not inhibit bacterial growth alone, and exhibits no cytotoxicity against HeLa cells, but it has potent bactericidal syergism with broad spectrum β-lactams, and may restore the clinical efficacy of existing β-lactam antibiotics.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1677-5MG:
SML1677-BULK:
SML1677-VAR:
SML1677-25MG:


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