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Safety Information

SML1584

Sigma-Aldrich

CMPPE

≥95% (HPLC)

Synonym(s):

2-[1-[2-(4-Chlorophenyl)-5-methylpyrazol[1,5-a]pyrimidin-7-yl]-2-piperidinyl]ethanol

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About This Item

Empirical Formula (Hill Notation):
C20H23ClN4O
CAS Number:
841253-81-4
Molecular Weight:
370.88
MDL number:
MFCD05710220
UNSPSC Code:
12352200
PubChem Substance ID:
329825972
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

ClC(C=C1)=CC=C1C2=NN(C(N3C(CCO)CCCC3)=CC(C)=N4)C4=C2

InChI

1S/C20H23ClN4O/c1-14-12-20(24-10-3-2-4-17(24)9-11-26)25-19(22-14)13-18(23-25)15-5-7-16(21)8-6-15/h5-8,12-13,17,26H,2-4,9-11H2,1H3

InChI key

TZWSGOPCLUTFBZ-UHFFFAOYSA-N

Biochem/physiol Actions

CMPPE is a GABAB receptor positive allosteric modulator (PAM). GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to mudulate GABA release and regulate K+ channels and Ca++ channels. CMPPE has the highest hypoactivity/anticonvulsant ratio.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1584-5MG:
SML1584-VAR:
SML1584-25MG:
SML1584-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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