Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

SML1509

Sigma-Aldrich

MK6-83

≥98% (HPLC)

Synonym(s):

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥19,200
25 MG
¥74,100

¥19,200

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
¥19,200
25 MG
¥74,100

About This Item

Empirical Formula (Hill Notation):
C16H20N2O2S2
CAS Number:
1062271-24-2
Molecular Weight:
336.47
UNSPSC Code:
12352200
NACRES:
NA.77

¥19,200

Check Cart for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(Nc2c(cccc2)N3CCCCC3)c1[s]c(cc1)C

InChI

1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3

InChI key

IRGYSXZCDAWOOC-UHFFFAOYSA-N

Biochem/physiol Actions

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel.
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1509-VAR:
SML1509-5MG:
SML1509-BULK:
SML1509-25MG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000242521
0000242520
0000284803
0000230409

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient?s Survival
Morelli MB, et al.
Cancers, 11(4), 525-525 (2019)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service