Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

SML1507

Sigma-Aldrich

CRT0066101 hydrochloride

≥98% (HPLC)

Synonym(s):

2-[4-((R)-2-Amino-butylamino)-pyrimidin-2-yl]-4-(1-methyl-1Hpyrazol-4-yl)-phenol hydrochloride, 2-[4-[[(2R)-2-Aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥16,170
25 MG
¥41,580

¥16,170

List Price¥23,100Save 30%

Estimated to ship onApril 06, 2025

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
¥16,170
25 MG
¥41,580

About This Item

Empirical Formula (Hill Notation):
C18H22N6O · xHCl
CAS Number:
956123-34-5
Molecular Weight:
338.41 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

¥16,170

List Price¥23,100Save 30%

Estimated to ship onApril 06, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

Cl.[n]1(ncc(c1)c2cc(c(cc2)O)c3nc(ccn3)NC[C@H](N)CC)C

InChI

1S/C18H22N6O.ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);1H/t14-;/m1./s1

InChI key

NBKRZGHHBBHLOQ-PFEQFJNWSA-N

Biochem/physiol Actions

CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms with IC50 values for PKD-1, -2 and -3 = 1, 2.5 and 2 nM, respecitively. CRT0066101 has been shown to have anticancer activity. CRT0066101 potently inhibits proliferation of PANC-1 pancreatic cells, and blocks migration and invasion of U87MG glioblastoma cells. CRT0066101 has also been shown to decrease growth of primary tumors and metastasis of ER(-) breast cancers.
CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1507-5MG:
SML1507-VAR:
SML1507-25MG:
SML1507-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000192676
0000192675
125M4734V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Peng Jiang et al.
Cell systems, 6(3), 343-354 (2018-02-13)
Identifying reliable drug response biomarkers is a significant challenge in cancer research. We present computational analysis of resistance (CARE), a computational method focused on targeted therapies, to infer genome-wide transcriptomic signatures of drug efficacy from cell line compound screens. CARE outputs

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service