SML1297

SB269652

≥98% (HPLC)

• Synonym(s): N-[trans-4-[2-(7-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-1H-indole-2-carboxamide
• Empirical Formula (Hill Notation): C₂₇H₃₀N₄O
• CAS Number: 215802-15-6
• Molecular Weight: 426.55
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(cc1C(=O)N[C@@H]3CC[C@H](CC3)CCN4CCc5c(cc(cc5)C#N)C4)cccc2
• InChI: 1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-
• InChI key: JGLGOAQPUQITLD-OGAOHHHESA-N

Description

Biochem/physiol Actions

Allosteric modulator of D2 dopamine receptors

SB269652 is an allosteric modulator of D2 dopamine receptors. SB269652 binds to an allosteric site that is distinct from the orthosteric bound by typical D2 antagonists and is only revealed in D2 receptor dimers. SB269652 is bitopic, binding to an orthosteric site one one partner in the dimer and the allosteric site in the other. Engagement of this secondary pocket at the extracellular end of TM2 and TM7 is a new mechanism of modulating binding of a ligand to the orthosteric site of a second protomer by a G-protein coupled receptor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable