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Safety Information

SML1189

Sigma-Aldrich

4-P-PDOT

≥98% (HPLC)

Synonym(s):

4-Phenyl-2-propionamidotetralin, 4P-PDOT, AH 024, N-(1,2,3,4-Tetrahydro-4-phenyl-2-naphthalenyl)-propanamide, cis-4-Phenyl-2-propionamidotetralin

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5 MG
¥21,500
25 MG
¥69,100

¥21,500

Estimated to ship onApril 13, 2025

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5 MG
¥21,500
25 MG
¥69,100

About This Item

Empirical Formula (Hill Notation):
C19H21NO
CAS Number:
134865-74-0
Molecular Weight:
279.38
UNSPSC Code:
12352200
NACRES:
NA.77

¥21,500

Estimated to ship onApril 13, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

N(C1CC(c3c(cccc3)C1)c2ccccc2)C(=O)CC

InChI

1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21)

InChI key

RCYLUNPFECYGDW-UHFFFAOYSA-N

Biochem/physiol Actions

4-P-PDOT is a slelctive MT2 melatonin receptor antagonist 300 fold selective for MT2 (MEL-1B-R) vs MT1 (MEL-1A-R) melatonin receptor subtype.
4-P-PDOT is a slelctive MT2 melatonin receptor antagonist.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1189-VAR:
SML1189-25MG:
SML1189-BULK:
SML1189-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000131381
0000077616
0000034556
0000034557
0000016531

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Shujuan Wang et al.
PeerJ, 9, e10627-e10627 (2021-03-19)
Granulosa cells play an essential physiological role in mediating the follicle development and survival or apoptosis of granulosa cells dictate the follicle development or atresia. The aim of this study was to investigate the role of high dose (10-5 M)
Jun Sung Kim et al.
Stem cell research & therapy, 12(1), 114-114 (2021-02-07)
Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are associated with apoptosis of engrafted umbilical cord blood-derived mesenchymal stem cells
Jingli Tao et al.
Autophagy, 14(11), 1850-1869 (2018-07-10)
To explore the anti-inflammatory activity of endogenous produced melatonin, a melatonin-enriched animal model (goat) with AANAT transfer was successfully generated with somatic cell nuclear transfer (SCNT) technology. Basically, a pIRES2-EGFP-AANAT expression vector was constructed and was transferred into the female
Jing-Li Tao et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-02-03)
In mammalian ovaries, the avascular environment within follicular cavity is supposed to cause hypoxic status in granulosa cells (GCs), leading to apoptotic cell death accompanied by cumulative reactive oxygen species (ROS) production. Melatonin (N-acetyl-5-methoxytryptamine, MT), a broad-spectrum antioxidant that exists

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