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SML1160

Sigma-Aldrich

CD40-TRAF6 signaling inhibitor

≥98% (HPLC)

Synonym(s):

3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one, Compound 6877002

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About This Item

Empirical Formula (Hill Notation):
C17H17NO
CAS Number:
433249-94-6
Molecular Weight:
251.32
UNSPSC Code:
51111800
PubChem Substance ID:
329825690
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C

InChI

1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+

InChI key

WIFPLULEUNBSTE-GZTJUZNOSA-N

Application

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

Biochem/physiol Actions

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1160-5MG:
SML1160-25MG:
SML1160-BULK:
SML1160-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.
Donners M M, et al.
Blood, 111(9), 4596-4604 (2008)
Philipp Hubel et al.
Nature immunology, 20(4), 493-502 (2019-03-06)
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to

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