The ENMD-1068 hydrochloride product, SML1039, exhibits a single absorbance maximum at 210 nanometers.
SML1039
ENMD-1068 hydrochloride
≥97% (HPLC)
Synonym(s):
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
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5 MG
¥19,200
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¥66,200
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5 MG
¥19,200
25 MG
¥66,200
About This Item
Empirical Formula (Hill Notation):
C15H29N3O2 · HCl
CAS Number:
Molecular Weight:
319.87
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 25 mg/mL, clear
storage temp.
2-8°C
SMILES string
N1(CCN(CC1)C(=O)CCCCCN)C(=O)CC(C)C
InChI
1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3
InChI key
VRZYMMVEALDDBH-UHFFFAOYSA-N
Application
ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2).[1]
Biochem/physiol Actions
ENMD-1068 hydrochloride exhibits anti-angiogenic and anti-inflammatory activities.[2]
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2).
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
SML1039-5MG:
SML1039-BULK:
SML1039-IP:
SML1039-25MG:
SML1039-VAR:
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Caroline R C Costa et al.
International journal of molecular sciences, 19(8) (2018-08-17)
Snake venom serine proteases (SVSPs) represent an essential group of enzymatic toxins involved in several pathophysiological effects on blood homeostasis. Some findings suggest the involvement of this class of enzymatic toxins in inflammation. In this paper, we purified and isolated
Yifeng Wang et al.
American journal of obstetrics and gynecology, 210(6), 531-531 (2014-02-06)
Protease-activated receptor 2 plays an important role in the pathogenesis of endometriosis. We studied the effect of ENMD-1068, a protease-activated receptor 2 antagonist, on the development of endometriosis in a noninvasive fluorescent mouse model. A red fluorescent protein-expressing xenograft model
Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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