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Safety Information

SML0619

Sigma-Aldrich

KG-548

≥97% (HPLC)

Synonym(s):

5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole

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About This Item

Empirical Formula (Hill Notation):
C9H4F6N4
CAS Number:
175205-09-1
Molecular Weight:
282.15
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C9H4F6N4/c10-8(11,12)5-1-4(7-16-18-19-17-7)2-6(3-5)9(13,14)15/h1-3H,(H,16,17,18,19)

InChI key

KKJFZIQEWZVVIV-UHFFFAOYSA-N

Biochem/physiol Actions

KG-548 is an inhibitor of the hypoxia signaling transcription factor complex. Hypoxia inducible factor (HIF) is a heterodimer of two bHLH-PAS (basic Helix Loop Helix - Per-ARNT-Sim) subunits, including a HIF-α paralog (HIF-1α, -2α, -3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β. KG-548 selectively binds within the ARNT PAS domain of the ARNT subunit of the HIF activator that recruits TACC3 (Transforming Acidic Coiled Coil Containing Protein 3) coactivator, competing with TACC3 for binding to the ARNT PAS-B domain and thus acting as as an ARNT/TACC3 disruptor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0619-25MG:
SML0619-5MG:
SML0619-VAR:
SML0619-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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