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Safety Information

SML0537

Sigma-Aldrich

MI-1

≥98% (HPLC)

Synonym(s):

4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-5,6,7,8-tetrahydro-[1]benzothieno[2,3-d]pyrimidine, CCG21397

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About This Item

Empirical Formula (Hill Notation):
C19H25N5S2
CAS Number:
433311-07-0
Molecular Weight:
387.57
MDL number:
MFCD03268791
UNSPSC Code:
12352202
PubChem Substance ID:
329825540
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution, warmed)

storage temp.

2-8°C

SMILES string

CC1(C)CN=C(S1)N2CCN(CC2)c3ncnc4sc5CCCCc5c34

InChI

1S/C19H25N5S2/c1-19(2)11-20-18(26-19)24-9-7-23(8-10-24)16-15-13-5-3-4-6-14(13)25-17(15)22-12-21-16/h12H,3-11H2,1-2H3

InChI key

MNSXQGKLDTVOLP-UHFFFAOYSA-N

Biochem/physiol Actions

MI-1 is a Menin-MLL interaction inhibitor. The mixed lineage leukemia (MLL) gene encodes MLL, a histone methyltransferase important in regulating gene transcription. MLL rearrangements and formation of fusion oncoproteins can block hematopoietic differentiation and increase proliferation, resulting in acute leukemias. Menin, encoded by the MEN1 gene, is a tumor suppressor associated with multiple endocrine neoplasia type 1. It also acts as an oncogenic co-factor of MLL fusion proteins. MI-1 inhibits Menin-MLL interaction with an IC50 of 1.9 micromolar.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0537-BULK:
SML0537-5MG:
SML0537-25MG:
SML0537-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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