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Safety Information

SML0509

Sigma-Aldrich

JK-P3

≥98% (HPLC)

Synonym(s):

3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide

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About This Item

Empirical Formula (Hill Notation):
C18H17N3O3
CAS Number:
942655-44-9
Molecular Weight:
323.35
MDL number:
MFCD22666405
UNSPSC Code:
12352200
PubChem Substance ID:
329825518
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

COc1ccc(cc1OC)C(=O)Nc2cc([nH]n2)-c3ccccc3

InChI

1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22)

InChI key

QAZJUVDICQNITG-UHFFFAOYSA-N

Biochem/physiol Actions

JK-P3 is a VEGFR-2 inhibitor.
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0509-25MG:
SML0509-VAR:
SML0509-BULK:
SML0509-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
102M4602V

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