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Safety Information

SML0413

Sigma-Aldrich

FQI1

≥98% (HPLC)

Synonym(s):

8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one

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About This Item

Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
599151-35-6
Molecular Weight:
311.33
MDL number:
MFCD03632583
UNSPSC Code:
12352200
PubChem Substance ID:
329825408
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1

InChI

1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)

InChI key

YKSYGLXHLSPWLB-UHFFFAOYSA-N

Biochem/physiol Actions

FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0413-VAR:
SML0413-BULK:
SML0413-25MG:
SML0413-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jennifer L S Willoughby et al.
BMC cancer, 20(1), 552-552 (2020-06-17)
The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and colorectal cancer. The limited treatment outcomes for
Seung Han Son et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(33), e2305096-e2305096 (2023-10-17)
Despite advances in precision oncology, cancer remains a global public health issue. In this report, proof-of-principle evidence is presented that a cell-penetrable peptide (ACP52C) dissociates transcription factor CP2c complexes and induces apoptosis in most CP2c oncogene-addicted cancer cells through transcription

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