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Safety Information

SML0389

Sigma-Aldrich

PF-514273

≥98% (HPLC)

Synonym(s):

2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one

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About This Item

Empirical Formula (Hill Notation):
C21H17Cl2F2N3O2
CAS Number:
851728-60-4
Molecular Weight:
452.28
MDL number:
MFCD12032112
UNSPSC Code:
12352202
PubChem Substance ID:
329825387
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL (warmed)

storage temp.

−20°C

SMILES string

CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O

InChI

1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3

InChI key

FJMQJSUOOGOWBD-UHFFFAOYSA-N

Biochem/physiol Actions

PF-514273 is a highly selective CB1 antagonist.
PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0389-25MG:
SML0389-VAR:
SML0389-BULK:
SML0389-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
062M4724V

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