MoTP may be used in cell signaling and differentiation studies.
Biochem/physiol Actions
Melanocytotoxic; reversibly blocks the specification of neural crest cells into melanocytes
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletogenic and pigment cell fates. Key transcription factors and extracellular signals
It has been reported that 5-hydroxytryptamine (5-HT) is related to melanogenesis in mice and melanoma cells. However, the underlying mechanisms of 5-HT in regulating pigmentation remains unknown. In this study, we aim to clarify the regulatory mechanism of 5-HT in
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
