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Safety Information

SCP0158

Sigma-Aldrich

Granzyme B Substrate

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):
C32H41N5O11
Molecular Weight:
671.69
UNSPSC Code:
12352204
NACRES:
NA.32
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Product Name

Granzyme B Substrate,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

Related Categories

Amino Acid Sequence

Ac-Ile-Glu-Pro-Asp-AMC

Application

Granzyme B Substrate (Ac-IEPD-AMC) is a fluorogenic substrate for the detection and assay of caspase 8 and granzyme B which is involved in the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Biochem/physiol Actions

Granzymes belongs to serine proteinase family enzymes and it localizes along with perforin in granules. It is predominant in cytotoxic T cells. Granzyme B induces caspases dependent and independent cell death. It possesses specific cleavage action at aspartate residue in the substrate.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SCP0158-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
LI0369

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Kazimierz Weglarczyk et al.
Infection and immunity, 72(5), 2590-2597 (2004-04-23)
Human peripheral blood monocytes become apoptotic following phagocytosis and killing of Staphylococcus aureus. Although this type of monocyte apoptosis is known to be initiated by Fas-Fas ligand (FasL) interactions, the downstream signaling pathway has not been determined. In this work
Hideaki Toda et al.
Veterinary immunology and immunopathology, 141(1-2), 168-172 (2011-03-26)
Granzyme B plays an important role in granule-mediated apoptosis by CTL. It is a well characterized component of the cytolytic machinery in mammals and a candidate for the evaluation of cytotoxic activity of CTL as an alternative to conventional cytotoxicity
Basic Concepts of Molecular Pathology, 32-32 (2009)
Fundamental Immunology, 1083-1083 (2008)
M Hayashida et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 225(2), 143-150 (2000-10-24)
Cell death induction by cytotoxic T lymphocytes (CTLs) is an important thesis for the understanding of tumor immunotherapy. In the current study we investigated the molecular machinery of CTL-induced cell death in human hepatocellular carcinoma cell lines (HCC lines). CTLs
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