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Safety Information

SAB4301167

Sigma-Aldrich

Anti-MTFP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

HSPC242, MTP18

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100 μL
¥58,700

¥58,700

Estimated to ship onMay 02, 2025

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100 μL
¥58,700

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

¥58,700

Estimated to ship onMay 02, 2025

New, lower price on this item!

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

18 kDa

species reactivity

human, mouse

concentration

1.8 mg/mL

technique(s)

immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)

isotype

IgG

accession no.

NP_001003704.1

UniProt accession no.

Q9UDX5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTFP1(51537)

General description

Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18), a nuclear-encoded integral protein, is located in the mitochondria. It is also a phosphatidylinositol 3-kinase-dependent protein. MTP18 comprises three α-helical stretches or transmembrane (TM) domains of high hydrophobicity. The MTFP1 gene is located on human chromosome 22q12.2.

Specificity

The antibody detects endogenous levels of total MTFP1 protein.

Immunogen

Fusion protein corresponding to a region derived from internal residues of human mitochondrial fission process 1

Application

Anti-MTFP1 antibody produced in rabbit has been used in western blot (1:1000).[1]

Biochem/physiol Actions

Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18) controls mitochondrial fission Hence it helps to maintain the morphology of the mitochondria. Overexpression of MTP18 can facilitate fragmentation of the mitochondria. Loss-of-function of MTFP1 protein promotes cell death. It is crucial for cell viability.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4301167-100UL:

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Certificates of Analysis (COA)

Lot/Batch Number
492636625

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Daniel Tondera et al.
Journal of cell science, 118(Pt 14), 3049-3059 (2005-06-30)
Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein complex assembled at the outer membrane. Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial
Aleix Prat et al.
Breast cancer research and treatment, 147(1), 185-191 (2014-07-23)
BRCA1-mutated breast cancer is associated with basal-like disease; however, it is currently unclear if the presence of a BRCA1 mutation depicts a different entity within this subgroup. In this study, we compared the molecular features among basal-like tumors with and
Daniel Tondera et al.
The Journal of biological chemistry, 279(30), 31544-31555 (2004-05-25)
We identified a novel human cDNA encoding a mitochondrial protein, MTP18 (mitochondrial protein, 18 kDa) as a transcriptional downstream target of phosphatidylinositol (PI) 3-kinase signaling. We demonstrate that MTP18 mRNA as well as protein expression is dependent on PI 3-kinase
Arne Jahn et al.
EMBO reports, 18(6), 929-946 (2017-05-14)
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated
Lynn H H Aung et al.
Clinical science (London, England : 1979), 133(9), 1067-1084 (2019-04-25)
Accumulation of reactive oxygen species is a common phenomenon in cardiac stress conditions, for instance, coronary artery disease, aging-related cardiovascular abnormalities, and exposure to cardiac stressors such as hydrogen peroxide (H2O2). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner

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