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Key Documents

Safety Information

SAB4100383

Sigma-Aldrich

Monoclonal Anti-TMOD1 antibody produced in mouse

clone TMOD1-A328, culture supernatant

Synonym(s):

Anti-D9S57E, Anti-ETMOD, Anti-TMOD, Anti-tropomodulin 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

TMOD1-A328, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 40.4 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2b

UniProt accession no.

P28289

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TMOD1(7111)

General description

Tropomodulin 1 (TMOD1) is an actin-capping protein, which is expressed in the cardiac muscle and in slow-twitch muscle fibers. It possesses two actin- and two tropomyosin (TM)-binding regions. The gene encoding this protein is localized on human chromosome 9q.

Immunogen

TMOD1 purified recombinant protein

Biochem/physiol Actions

Tropomodulin 1 (TMOD1) prevents the elongation and depolymerization of actin filaments by binding to the slowly growing pointed end of the actin filament. It has been associated with triple-negative breast cancers (TNBC). TMOD1 may act as a stabilizer of β-catenin.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4100383-200UL:

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Certificates of Analysis (COA)

Lot/Batch Number

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Tropomodulin 1 Expression Driven by NF-?B Enhances Breast Cancer Growth
Taku Ito-Kureha
Cancer Research, 75(1) (2015)
Complete trisomy 9 with unusual phenotypic associations: Dandy-Walker malformation, cleft lip and cleft palate, cardiovascular abnormalities
Gabriele Tonni, et.al
Taiwanese Journal of Obstetrics & Gynecology, 53(4), 592-597 (2014)
Leucine 135 of Tropomodulin-1 Regulates Its Association with Tropomyosin, Its Cellular Localization, and the Integrity of Sarcomeres*
Kimi Y and Larry Kedes
The Journal of Biological Chemistry (2006)
Complete trisomy 9 with unusual phenotypic associations: Dandy-Walker malformation, cleft lip and cleft palate, cardiovascular abnormalities
GabrieleTonni
Taiwanese Journal of Obstetrics & Gynecology, 53(4), 592-597 (2014)
Mechanism of actin filament pointed end capping by tropomodulin
Jampani Nageswara Rao
Science, 345(6195), 463-467 (2014)

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