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Safety Information

SAB2700185

Sigma-Aldrich

Anti-Gli1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

AV235269, Gli1, Zfp-5, Zfp5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1:500-1:3000

NCBI accession no.

NP_034426

UniProt accession no.

P08151

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Gli1(14632)

General description

GLI-Kruppel family member Gli1 is a transcriptional activator, which is part of the Gli family of transcription factors. It is a target of hedgehog signaling.

Immunogen

Synthetic peptide containing a sequence corresponding to a region within amino acids 755 and 810 of Gli1 according to NP_034426

Application

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

GLI-Kruppel family member Gli1 may regulate the transcription of specific genes during normal development. It may also play a role in osteoblast formation, craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. The protein mediates SHH signaling and thus cell proliferation and differentiation. Gli1 may also be involved in tissue repair in pancreas. This protein has a protective role during stroke, ischemic injury and Parkinson′s disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H412

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB2700185-100UG:
SAB2700185-100UL:4548173332413

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.
Kitaura Y
PLoS ONE (2014)
Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor ?1 in mice.
McMillin M
Journal of Hepatology (2014)
The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
Mathew E
The Journal of Biological Chemistry (2014)
Anusha et al.
Cell death & disease, 12(3), 259-259 (2021-03-13)
Chronic myeloid leukemia (CML) patients with complex chromosomal translocations as well as non-compliant CML patients often demonstrate short-lived responses and poor outcomes on the current therapeutic regimes using Imatinib and its variants. It has been derived so far that leukemic
Fengjiao Liu et al.
CNS neuroscience & therapeutics, 27(12), 1518-1530 (2021-09-05)
Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH-MB) is one of the major subtypes of MB in the clinic. However, the molecular mechanisms underlying MB tumorigenesis are

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