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Safety Information

SAB1304901

Sigma-Aldrich

ANTI-CCL22 (CENTER) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

C-C motif chemokine 22, CCL22, MDC, SCYA22

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

antibody form

IgG fraction of antiserum

Quality Level

100

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

10625 Da

species reactivity

human

technique(s)

western blot: 1:250-1:500

NCBI accession no.

NP_002981.2

UniProt accession no.

O00626

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCL22(6367)

General description

Macrophage-derived chemokine (MDC) is also known as C-C motif chemokine ligand 22 (CCL22). It is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and cluster of differentiation 4 (CD4) T cells. The gene encoding it is localized on human chromosome 16. Recombinant human MDC is an 8.0kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Biochem/physiol Actions

Macrophage-derived chemokine (MDC) signals through the C-C chemokine receptor type 4 (CCR4). It chemo-attracts monocytes, dendritic cells and natural killer (NK) cells and aids in their function. The protein exerts human immunodeficiency virus (HIV) suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. It is expressed in various cancers and is involved in recruitment of regulatory T cells (Treg) within a tumor.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB1304901-100UG:
SAB1304901-400UL:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dong Wang et al.
Cancer letters, 452, 244-253 (2019-04-01)
Immune dysfunction often occurs in malignant pleural effusion (MPE). In our previous study, TGF-β derived predominantly from macrophages plays an important role in impairing T cell cytotoxicity in MPE. Therefore, we aimed to investigate whether other immunoregulatory cells and factors
Satoshi Kimura et al.
Journal of atherosclerosis and thrombosis, 25(12), 1240-1254 (2018-05-26)
CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines and is involved in monocyte migration and recruitment. We have previously investigated CCL22 and histamine in atherosclerosis. Here, we investigated the hypothesis that CCL22 is
Hai-Xiang Gao et al.
Experimental lung research, 45(1-2), 1-12 (2019-04-30)
Objective: To study the role of miR-34c-5p targeting CCL22 in affecting the progression of chronic obstructive pulmonary disease (COPD). Methods: The dual-luciferase reporter gene assay was applied to verify the targeting relationship of miR-34c-5p and CCL22. The rats were randomly
Suppression of intratumoral CCL22 by type i interferon inhibits migration of regulatory T cells and blocks cancer progression.
Anz D
Cancer Research, 75(21), 4483-4493 (2015)
Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of ? chemokines and RNases.
Cocchi F
Proceedings of the National Academy of Sciences of the USA, 109(14), 5411-5416 (2012)
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