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Safety Information

R8019

Sigma-Aldrich

Ribonucleic acid, transfer, N-formylmethionine specific from Escherichia coli MRE 600

lyophilized powder

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About This Item

MDL number:
MFCD00132200
UNSPSC Code:
41106305

form

lyophilized powder

storage temp.

−20°C

Application

Ribonucleic acid, transfer, N-formylmethionine-specific may be used as a substrate to study the specifity and kinetics of natural, mutated and chemically engineered N-formylmethionine-specific E. coli aminoacyl-tRNA synthetase(s) and methionyl-tRNA formyltransferase(s) (MTF).

Quality

Acceptor Activity: ≥ 1000 picomoles methionine per A260 unit.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

R8019-10UN:
R8019-PPG:
R8019-VAR:
R8019-BULK:
R8019-PH:
R8019-50UN:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thomas E Jones et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 6933-6938 (2011-04-13)
Aminoacyl-tRNA synthetases perform a critical step in translation by aminoacylating tRNAs with their cognate amino acids. Although high fidelity of aminoacyl-tRNA synthetases is often thought to be essential for cell biology, recent studies indicate that cells tolerate and may even
I Caglar Tanrikulu et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15285-15290 (2009-08-27)
Incorporation of noncanonical amino acids into cellular proteins often requires engineering new aminoacyl-tRNA synthetase activity into the cell. A screening strategy that relies on cell-surface display of reactive amino acid side-chains was used to identify a diverse set of methionyl-tRNA
Diya M Abdeljabbar et al.
Journal of the American Chemical Society, 131(47), 17078-17079 (2009-11-10)
Engineered aminoacyl-tRNA synthetases have been used to enable the incorporation of many unnatural amino acids into recombinant proteins in vivo. In the majority of these studies, the engineered synthetase is harbored on a plasmid while the host retains a wild-type
M A Deniziak et al.
Acta biochimica Polonica, 48(2), 337-350 (2001-12-06)
Methionyl-tRNA synthetase (MetRS) belongs to the family of 20 enzymes essential for protein biosynthesis. It links covalently methionine with its cognate tRNA. Crystal structures solved for bacterial MetRSs have given a number of interesting insights into enzyme architecture and methionylation
V Ramesh et al.
Biochemistry, 37(45), 15925-15932 (1998-12-08)
Formylation of initiator methionyl-tRNA by methionyl-tRNA formyltransferase (MTF) is important for initiation of protein synthesis in eubacteria. The determinants for formylation are clustered mostly in the acceptor stem of the initiator tRNA. Previous studies suggested that a 16 amino acid

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