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R3405

Sigma-Aldrich

RP-107

≥98% (HPLC), solid

Synonym(s):

7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine

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About This Item

Empirical Formula (Hill Notation):
C16H17N3O
CAS Number:
496864-15-4
Molecular Weight:
267.33
MDL number:
MFCD04973541
UNSPSC Code:
12352200
PubChem Substance ID:
329824024

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3

InChI

1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)

InChI key

PRIGRJPRGZCFAS-UHFFFAOYSA-N

Biochem/physiol Actions

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

R3405-BULK:
R3405-5MG:
R3405-VAR:
R3405-25MG:

Certificates of Analysis (COA)

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