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Safety Information

P7575

Sigma-Aldrich

L-trans-Pyrrolidine-2,4-dicarboxylic acid

≥98%

Synonym(s):

(2S,4R)-Pyrrolidine-2,4-Dicarboxylic Acid, L-trans-2,4-PDC, trans-4-Carboxy-L-proline

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2 MG
¥11,700
10 MG
¥29,800

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2 MG
¥11,700
10 MG
¥29,800

About This Item

Empirical Formula (Hill Notation):
C6H9NO4
CAS Number:
64769-66-0
Molecular Weight:
159.14
MDL number:
MFCD00153866
UNSPSC Code:
12352106
PubChem Substance ID:
24898859
NACRES:
NA.77

¥11,700

Estimated to ship onFebruary 17, 2025Details

New, lower price on this item!
Request a Bulk Order

Quality Level

100

Assay

≥98%

form

powder

SMILES string

OC(=O)[C@H]1CN[C@@H](C1)C(O)=O

InChI

1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1

InChI key

NRSBQSJHFYZIPH-DMTCNVIQSA-N

Gene Information

rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Slc1a2(29482) , Slc1a3(29483)

Related Categories

Application

L-trans-Pyrrolidine-2,4-dicarboxylic acid has been used:
  • as a glutamate transport inhibitor to test its impairing effect on glutamate-induced cell death in HT22 neuronal cells[1]
  • as an analog of glutamate to test its effect on glutamate/glutamine-dependent acid resistance of E. coli and S. flexneri[2]
  • as sodium glutamate (Na+/Glu) cotransporter inhibitor in myogenic cell line C2C12[3]

Biochem/physiol Actions

L-trans-Pyrrolidine-2,4-dicarboxylic acid is a selective glutamate transporter inhibitor.[1]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P7575-VAR:
P7575-10MG:
P7575-BULK:
P7575-2MG:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV1978
MKCP6672
MKCN3978
MKCK8566
MKCD3903

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H-R Weng et al.
Neuroscience, 138(4), 1351-1360 (2006-01-24)
Glutamate is a primary excitatory neurotransmitter in the mammalian CNS. Glutamate released from presynaptic neurons is cleared from the synaptic cleft passively by diffusion and actively by glutamate transporters. In this study, the role of glutamate transporters in sensory processing
Yingmei Zhang et al.
CNS neuroscience & therapeutics, 30(1), e14487-e14487 (2023-10-07)
Chronic cerebral hypoperfusion-induced demyelination causes progressive white matter injury, although the pathogenic pathways are unknown. The Single Cell Portal and PanglaoDB databases were used to analyze single-cell RNA sequencing experiments to determine the pattern of EAAT3 expression in CNS cells.
V J Balcar
FEBS letters, 300(3), 203-207 (1992-04-06)
Uptake of 1 microM [3H]L-glutamate by cultured 3T3 fibroblasts was strongly dependent on extracellular Na+; it was reduced by elevated concentrations of K+ (60 mM) but it was not influenced by variations in the concentration of Ca2+ (0-9.6 mM). D-
George J Kallingal et al.
The European journal of neuroscience, 24(10), 2853-2858 (2006-12-13)
Previous studies have established that microinjection of gastrin-releasing peptide (GRP) into the suprachiasmatic nucleus (SCN) region or third ventricle causes circadian phase shifts similar to those produced by light pulses. Activation of N-methyl-d-aspartate (NMDA) receptors in the SCN region also
Younglim Lee et al.
Psychopharmacology, 191(1), 55-65 (2007-01-17)
Recent evidence in clinical and preclinical studies has implicated glutamate neurotransmissions in pathophysiology of mood disorders. The regulation of amino acid neurotransmission, i.e., glutamate and gamma-aminobutyric acid (GABA) involves coordinated mechanisms of uptake and transport within a tripartite synaptic system
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