P6102

Anti-Potassium Channel K_ir2.1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-ATFB9, Anti-HHBIRK1, Anti-HHIRK1, Anti-IRK1, Anti-KIR2.1, Anti-LQT7, Anti-SQT3
• MDL number: MFCD02686542
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: IHC; WB CL
• clone: polyclonal
• species reactivity: rat
• citations: 5
• technique(s): immunohistochemistry: suitable; western blot (chemiluminescent): 1:200

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): immunohistochemistry: suitable; western blot (chemiluminescent): 1:200
• UniProt accession no.: Q64273
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... KCNJ2(3759) ; mouse ... Kcnj2(16518) ; rat ... Kcnj2(29712)

Description

General description

Potassium voltage-gated channel subfamily J member 2 (KCNJ2) is an inward-rectifying potassium channel. This tetrameric protein possesses two transmembrane helix domains (M1 and M2), an ion-selective P-loop between M1 and M2 and cytoplasmic amino and carboxy-terminal domains. The gene encoding KCNJ2 is localized on human chromosome 17q24.3.

Immunogen

synthetic peptide corresponding to amino acids 392-410 of human Kir2.1 (with additional N-terminal cysteine). This epitope is identical in rabbit, bovine, pig, and guinea pig and highly homologous in rat, mouse and chicken.

Biochem/physiol Actions

Potassium voltage-gated channel subfamily J member 2 (KCNJ2) has been shown to have a role in the differentiation and proliferation of bone marrow-derived macrophages (BMDM) in mice. It allows the inward movement of K⁺ into the cell and maintains its balance. Mutations in the KCNJ2 gene have been linked to Andersen-Tawil syndrome.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H312 + H332,H412
• Precautionary Statements: P261 - P271 - P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable