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Safety Information

P5864

Sigma-Aldrich

Proteoglycan from bovine nasal septum

chromatographically purified

Synonym(s):

Bovine Proteoglycan, Nasal Proteoglycan

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10 MG
¥72,800

¥72,800

List Price¥104,000Save 30%

Estimated to ship onApril 06, 2025

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10 MG
¥72,800

About This Item

MDL number:
MFCD00212609
UNSPSC Code:
12352202
NACRES:
NA.61

¥72,800

List Price¥104,000Save 30%

Estimated to ship onApril 06, 2025

New, lower price on this item!
Request a Bulk Order

biological source

bovine nasal septum

Quality Level

100

form

powder

technique(s)

cell culture | stem cell: suitable

UniProt accession no.

F1MDS0

storage temp.

−20°C

Gene Information

bovine ... PRG4(280867)

General description

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Application

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture. [1]
Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Biochem/physiol Actions

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Preparation Note

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P5864-10MG-PW:
P5864-10MG:
P5864-VAR:
P5864-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP8438
MKCN6587
MKCM7163
MKCM0990
MKCK0607

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Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to

Articles

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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