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Key Documents

Safety Information

P4107

Sigma-Aldrich

[Leu31, Pro34]-Peptide YY

≥95%

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About This Item

Empirical Formula (Hill Notation):
C195H296N54O56
Molecular Weight:
4292.76
MDL number:
MFCD00678656
UNSPSC Code:
12352209
NACRES:
NA.32

Quality Level

200

Assay

≥95%

form

powder

UniProt accession no.

P10082

storage temp.

−20°C

Gene Information

human ... PYY(5697)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Leu-Thr-Arg-Pro-Arg-Tyr-NH2

Biochem/physiol Actions

Agonist at Y1, Y4, and Y5 NPY receptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P4107-VAR:
P4107-BULK:
P4107-.5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Gobbi et al.
Journal of neurochemistry, 72(4), 1663-1670 (1999-03-31)
125I-[Leu31,Pro34]peptide YY (PYY) and 125I-PYY3-36, initially described as selective neuropeptide Y Y1 and Y2 receptor ligands, respectively, were recently shown to label also Y4 and Y5 receptors. We used receptor autoradiography to assess whether these ligands can be reliably used
L Ferrier et al.
Gut, 46(3), 370-375 (2000-02-15)
Peptide YY (PYY) is involved in the regulation of several gut functions, including secretion and motility. It exerts its effects through a family of six receptors, commonly named the Y receptor family. To characterise the effects of PYY on strips
Ross A Carson et al.
PloS one, 13(5), e0196387-e0196387 (2018-05-09)
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway (CBP), and are used for the prevention of cardiovascular disease. The anti-inflammatory effects of statins may also provide therapeutic benefits and have led to their use in clinical
Y Dumont et al.
Canadian journal of physiology and pharmacology, 78(2), 116-125 (2000-03-29)
We have evaluated 3 newly developed neuropeptide Y receptor antagonists in various in vitro binding and bioassays: BIBO3304 (Y1), T4[NPY33-36]4 (Y2), and CGP71683A (Y5). In rat brain homogenates, BIBO3304 competes for the same population of [125I][Leu31,Pro34] peptide YY (PYY) binding
Xiaohong Yang et al.
Frontiers in bioengineering and biotechnology, 8, 468-468 (2020-06-18)
Effective clinical treatments of cartilage lesions in affected joints require large numbers of viable chondrogenic cells generated through in vivo stimulation or ex vivo expansion of chondrocytes isolated from small biopsy specimens. Conventional passaging of chondrocytes in culture provides sufficient
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