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P3493

Sigma-Aldrich

Monoclonal Anti-Placenta Growth Factor-2 antibody produced in rat

clone 62526, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-PlGF-2

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About This Item

MDL number:
MFCD02097209
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

rat

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

62526, monoclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL

isotype

IgG2a

UniProt accession no.

P49764

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Pgf(18654)

General description

The antibody neutralizes receptor-ligand interaction. The antibody shows no cross-reactivity with recombinant human PlGF and recombinant human VEGF.

Immunogen

purified recombinant mouse placenta growth factor 2 expressed in insect Sf 21 cells.

Biochem/physiol Actions

Placental growth factors (PlGF) are involved in the growth, migration and survival of endothelial cells. All the four isoforms identified are expressed in placenta and umbilical vein endothelial cells. PlGF bind to specific Flt-1 receptors that result in activation and recruitment of dendritic cells, smooth muscle cells and inflammatory cells. PlGF2 has the ability to bind heparin while PlGF1 is a soluble isoform.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P3493-500UG-PW:
P3493-500UG:
P3493-BULK:
P3493-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Valeria Tarallo et al.
American journal of cancer research, 1(2), 265-274 (2011-10-05)
Angiogenesis is one of the crucial events for cancer development and growth and vascular endothelial growth factor (VEGF) family plays an essential role in this biological phenomenon. The members of VEGF family mainly involved in angiogenesis are VEGF-A, VEGF-B and
S C W Tang et al.
Kidney international, 73(3), 288-299 (2007-11-23)
Angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and statins have renoprotective effects. We studied the cellular mechanisms for this effect in adriamycin-treated mice receiving captopril, losartan, simvastatin, or their combinations. The mice developed albuminuria, renal insufficiency, and parenchymal inflammation/fibrosis accompanied

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