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Safety Information

P169

Supelco

Protriptyline hydrochloride

Synonym(s):

N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21N · HCl
CAS Number:
1225-55-4
Molecular Weight:
299.84
EC Number:
214-956-3
MDL number:
MFCD00072057
UNSPSC Code:
41116107

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

SMILES string

Cl[H].CNCCCC1c2ccccc2C=Cc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

InChI key

OGQDIIKRQRZXJH-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Product No.
Description
Pricing

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P169-100MG:
P169-VAR:
P169-25MG:
P169-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C C Lin
Journal of the Formosan Medical Association = Taiwan yi zhi, 92 Suppl 4, S232-S236 (1993-12-01)
To determine the effects of protriptyline, a tricyclic non-sedative antidepressant, on sleep architecture, day and night arterial oxygen saturation and pulmonary function, ten patients with stable chronic obstructive pulmonary disease were evaluated. Overnight polysomnographic measurements were made before and 2
R E Dahl et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 33(6), 834-841 (1994-07-01)
Although narcolepsy is rarely diagnosed before adulthood, symptoms often begin much earlier and can easily mimic psychiatric disorders in children and adolescents. Clinical experience from a pediatric sleep center is reviewed in 16 consecutive cases of polysomnographically proven narcolepsy with
Y Oku et al.
Respiration physiology, 93(1), 41-49 (1993-07-01)
Protriptyline (PRT) has been shown to preferentially stimulate upper airway inspiratory motorneurons relative to phrenic activity in hyperoxic hypercapnia in the decerebrate cat via a carotid body-independent mechanism. Since previous studies indicated that carotid body stimulation results in preferential activation
P Lévy et al.
Sleep, 19(9 Suppl), S101-S110 (1996-11-01)
The spectrum of respiratory sleep disorders has been extended in the last years to include conditions that are less well defined than severe obstructive sleep apnea (OSA). Moderate OSA, snoring, and upper airway resistance syndrome (UARS) represent three conditions in
G M Barthlen
Respiration; international review of thoracic diseases, 64 Suppl 1, 35-38 (1997-01-01)
Patients with neuromuscular disease may suffer from nocturnal respiratory failure despite normal daytime respiratory function. The physiological reduction in muscle tone during sleep may be life-threatening in a patient with impaired muscle strength. Nocturnal respiratory failure may occur in patients
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