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Safety Information

P0713

Sigma-Aldrich

Anti-Protein Kinase Cζ antibody produced in rabbit

whole antiserum

Synonym(s):

Anti-PKC ζ

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About This Item

MDL number:
MFCD00162775
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

mol wt

antigen 78 kDa

contains

15 mM sodium azide

species reactivity

rat, mouse

technique(s)

microarray: suitable
western blot: suitable using rat brain extract and mouse NIH3T3 fibroblast cell lysate

UniProt accession no.

Q02956

shipped in

dry ice

storage temp.

−20°C

Gene Information

mouse ... Prkcz(18762)
rat ... Prkcz(25522)

General description

Protein Kinase C (PKC) is a 76-93 kD phospholipid-dependent enzyme that belongs to serine/threonine protein kinases family. It has a pivotal role in cell growth and differentiation, modulation of neurotransmission, signal transduction and oncogenesis. PKC ζ isoform is expressed mainly in many cells and tissues and is activated by cis- unsaturated fatty acids. Anti-protein kinase C ζ antibody can be used for studying differential tissue expression and intracellular localization of PKC ζ. It can also be used for studying PKC expression in normal and neoplastic tissues. Rabbit anti-protein kinase C ζ antibody reacts specifically with PKC ζ (78 kD) from rat brain extract. The product is also specific for PKC ζ (78-80 kD proteins appearing as doublet) from NIH 3T3 mouse fibroblasts lysate.

Immunogen

Synthetic peptide corresponding to the C-terminal variable (V5) region (amino acids 577-592) of PKC ζ coupled to KLH.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month.For extended storage freeze in working aliquots.Repeated freezing and thawing is not recommended.Storage in "frost-free" freezers is not recommended. Ifslight turbidity occurs upon prolonged storage, clarifythe solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P0713-.2ML:
P0713-VAR:
P0713-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
057K4815
106K4816
122K4805
113K4826
036H4838

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Y Nishizuka
Science (New York, N.Y.), 258(5082), 607-614 (1992-10-23)
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to intracellular events through activation
Elena Rainero et al.
PloS one, 9(6), e97144-e97144 (2014-06-03)
Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cytoskeletal remodeling and matrix invasion by recruiting atypical
Yimin Zhu et al.
Cellular signalling, 17(9), 1125-1136 (2005-07-05)
Protein kinase C (PKC) is a family of serine/threonine protein kinases that are pivotal in cellular regulation. Since its discovery in 1977, PKCs have been known as cytosolic and peripheral membrane proteins. However, there are reports that PKC can insert
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
He Q, Wang G, Wakade S, et al.
Molecular Biology of the Cell, 25(11), 1715-1729 (2014)
Holly E Lovegrove et al.
Development (Cambridge, England), 146(23) (2019-12-01)
The Drosophila egg chamber comprises a germline cyst surrounded by a tightly organised epithelial monolayer, the follicular epithelium (FE). Loss of integrin function from the FE disrupts epithelial organisation at egg chamber termini, but the cause of this phenotype remains
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