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O9126

Sigma-Aldrich

Oxotremorine sesquifumarate salt

≥98% (HPLC), solid

Synonym(s):

1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone, 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone

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About This Item

Empirical Formula (Hill Notation):
C12H18N2O · 1.5C4H4O4 · xH2O
CAS Number:
17360-35-9
Molecular Weight:
380.39 (anhydrous basis)
EC Number:
241-388-3
MDL number:
MFCD00013163
UNSPSC Code:
12352200
PubChem Substance ID:
24278614
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

mp

102-105 °C (lit.)

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.O=C1CCCN1CC#CCN2CCCC2.O=C3CCCN3CC#CCN4CCCC4

InChI

1S/2C12H18N2O.3C4H4O4/c2*15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13;3*5-3(6)1-2-4(7)8/h2*1-2,5-11H2;3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+

InChI key

WLYYOFJEBGHKEC-VQYXCCSOSA-N

Gene Information

human ... CHRM2(1129)

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Biochem/physiol Actions

Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M2 receptor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

O9126-VAR:
O9126-BULK:
O9126-1G:
O9126-500MG:
O9126-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000083831
0000077578
0000077577
0000064706
0000064707

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S Shabani et al.
Neuroscience, 170(2), 559-569 (2010-07-30)
The cholinergic input from the lateral dorsal tegmental area (LDTg) modulates the dopamine cells of the ventral tegmental area (VTA) and plays an important role in cocaine taking. Specific pharmacological agents that block or stimulate muscarinic receptors in the LDTg
An in vivo pharmacological study on muscarinic receptor subtypes regulating cholinergic neurotransmission in rat striatum.
S Consolo et al.
Biochemical pharmacology, 36(18), 3075-3077 (1987-09-15)
I Izquierdo et al.
Pharmacology, biochemistry, and behavior, 33(3), 545-548 (1989-07-01)
CD-1 mice were trained in a classically conditioned emotional response paradigm and tested 24 hr later. Exposure to an open field 0 or 1, but not 3 hr after training retroactively interfered with retention of the conditioned emotional response. The
D H Overstreet et al.
Biological psychiatry, 21(7), 657-664 (1986-06-01)
Immobility during forced swimming or after mild footshock (1 mA for 2 sec) was observed in five groups of rats. The Flinders Sensitive Line (FSL) of rats, known to be more sensitive to cholinergic agonists, exhibited the greatest degree of
Sebastien Carnicella et al.
Psychopharmacology, 178(4), 533-541 (2005-02-08)
In a companion study (Carnicella et al., 2005), we showed that the muscarinic antagonist atropine, when administered after extensive training during both conditioning and testing, affected neither cued nor contextual fear memories when both of them did not compete for
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