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Safety Information

N7627

Sigma-Aldrich

L-Norvaline

≥99% (TLC)

Synonym(s):

(S)-(+)-2-Aminopentanoic acid, (S)-2-Aminovaleric acid

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About This Item

Linear Formula:
CH3CH2CH2CH(NH2)CO2H
CAS Number:
6600-40-4
Molecular Weight:
117.15
Beilstein:
1721162
EC Number:
229-543-3
MDL number:
MFCD00064421
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24897833
NACRES:
NA.26

product name

L-Norvaline, arginase inhibitor

Assay

≥99% (TLC)

form

powder

color

white

mp

>300 °C (lit.)

application(s)

detection

SMILES string

CCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI key

SNDPXSYFESPGGJ-BYPYZUCNSA-N

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Related Categories

Application


  • Nanodrugs mediate TAMs-related arginine metabolism interference to boost photodynamic immunotherapy.: This study explores the use of nanodrugs to interfere with arginine metabolism in tumor-associated macrophages (TAMs), enhancing the efficacy of photodynamic immunotherapy. L-Norvaline plays a crucial role in this metabolic interference (Chen et al., 2024).

Biochem/physiol Actions

L-Norvaline enhances NO production from activated macrophages.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N7627-BULK:
N7627-1G:
N7627-10G:
N7627-5G:
N7627-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C I Chang et al.
The American journal of physiology, 274(1 Pt 2), H342-H348 (1998-02-12)
In macrophages and many other cell types, L-arginine is used as a substrate by both nitric oxide synthase (NOS) and arginase to produce nitric oxide (NO) and urea, respectively. Because the availability of L-arginine is a major determinant for NO
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Increased arginase activity has been reported in a variety of disease conditions characterized by vascular dysfunction. In the present study, the potentially protective effect of arginase inhibition against the hypertension associated with diabetes has been investigated. Diabetes was induced by
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