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Safety Information

N7001

Sigma-Aldrich

2-Nitro-4-carboxyphenyl N,N-diphenylcarbamate

Synonym(s):

NCDC

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About This Item

Empirical Formula (Hill Notation):
C20H14N2O6
CAS Number:
10556-88-4
Molecular Weight:
378.33
MDL number:
MFCD00057605
UNSPSC Code:
12352202

SMILES string

OC(=O)c1ccc(OC(=O)N(c2ccccc2)c3ccccc3)c(c1)N(=O)=O

Application

Can be used for the determination of chymotrypsin; liberates 4-hydroxy-3-nitrobenzoic acid (also available from Sigma).

Biochem/physiol Actions

Specific chromogenic inactivator of chymotrypsin. Inhibits anti-IgE-mediated histamine release and inositol trisphosphate (IP3) production in mast cells, possibly by a mechanism involving inhibition of phospholipase C (PLC).[1]

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N7001-500MG:
N7001-5G:
N7001-BULK:
N7001-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
096H0487
083K0591
041H0419
045H1513

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M Takei et al.
Biochemical and biophysical research communications, 181(3), 1313-1322 (1991-12-31)
NCDC dose-dependently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Moreover, NCDC inhibited Ca(2+)-mobilization from intracellular Ca(2+)-stores as well as histamine release in mast cells activated by anti IgE, the effect on both of these phenomena being
THE UTILIZATION OF A SPECIFIC CHROMOGENIC INACTIVATOR IN AN "ALL OR NONE" ASSAY FOR CHYMOTRYPSIN.
B F ERLANGER et al.
Biochemistry, 3, 346-349 (1964-03-01)

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