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N6784

Sigma-Aldrich

Noggin/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

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About This Item

MDL number:
MFCD03457756
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

mouse

Quality Level

100

recombinant

expressed in NSO cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

55-60 kDa by SDS-PAGE (reducing)
calculated mol wt 50 kDa

packaging

pkg of 50 μg

impurities

endotoxin, tested

UniProt accession no.

P97466

storage temp.

−20°C

Gene Information

mouse ... Nog(18121)

Biochem/physiol Actions

Binds and blocks the acitivity of bone morphogenetic proteins (BMPs). Mature mouse noggin shares 99% and 83% sequence identity with human and Xenopus noggin, respectively.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human BMP-4 induced alkaline phosphatase activity in ATDC5 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N6784-50UG-PW:
N6784-VAR:
N6784-50UG:
N6784-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse.
Wijgerde M
Developmental Biology (2005)
TGF-beta superfamily members and ovarian follicle development.
Knight PG and Glister C
Reproduction (Cambridge, England) (2006)
The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues.
Laurila R
International Journal of Clinical and Experimental Pathology (2013)
D A Lim et al.
Neuron, 28(3), 713-726 (2001-02-13)
Large numbers of new neurons are born continuously in the adult subventricular zone (SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the bone morphogenetic protein (BMP) antagonist Noggin is expressed by ependymal cells
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice.
Wu XB
The Journal of Clinical Investigation (2003)
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