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Safety Information

N6127

Sigma-Aldrich

19-Norethindrone acetate

Synonym(s):

17α-Ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate, 17α-Ethynyl-19-nortestosterone 17β-acetate, 17-Hydroxy-19-nor-17α-4-pregnen-20-yn-3-one acetate, 19-Norethisterone 17-acetate

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About This Item

Empirical Formula (Hill Notation):
C22H28O3
CAS Number:
51-98-9
Molecular Weight:
340.46
EC Number:
200-132-0
MDL number:
MFCD00271615
UNSPSC Code:
41116107
PubChem Substance ID:
24897767

Assay

≥98.00% (HPLC)

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1

InChI key

IMONTRJLAWHYGT-ZCPXKWAGSA-N

Gene Information

human ... PGR(5241)

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Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H351,H360FD,H362,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N6127-VAR:
N6127-1G:
N6127-100MG:
N6127-500MG:
N6127-5G:
N6127-BULK:

Certificates of Analysis (COA)

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Eija Pöllänen et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 20(5), 372-379 (2010-08-21)
To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double
Anieta M Sieuwerts et al.
Molecular oncology, 5(6), 504-516 (2011-10-01)
Risk assessment of future breast cancer risk through exposure to sex steroids currently relies on clinical scorings such as mammographic density. Knowledge about the gene expression patterns in existing breast cancer tumors may be used to identify risk factors in
D J Kaser et al.
Journal of pediatric and adolescent gynecology, 25(2), 105-108 (2011-12-14)
To evaluate the efficacy and tolerability of norethindrone acetate (NA) as single-agent hormonal therapy for suppression of endometriosis symptoms in adolescents and young adults. Retrospective study. Two academic medical centers. A keyword search using the query 'NA' was applied to
Marjo Tuppurainen et al.
Maturitas, 66(4), 423-430 (2010-06-16)
To determine the effects of HRT with or without clodronate on bone mineral density (BMD) change and bone turnover markers. Prospective, partly randomized trial. Kuopio University Hospital, Finland. 167 osteoporotic women (61+/-2.7 years; T-score<or=-2.5 SD). Estradiol 2 mg+NETA 1 mg
Donita Africander et al.
Contraception, 84(4), 423-435 (2011-09-17)
Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been
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