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N4377

Sigma-Aldrich

4-Nitrophenyl valerate

chromogenic, ≥98% (TLC), liquid

Synonym(s):

Pentanoic acid 4-nitrophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C11H13NO4
CAS Number:
1956-07-6
Molecular Weight:
223.23
MDL number:
MFCD00057614
UNSPSC Code:
12352204
PubChem Substance ID:
24897702
NACRES:
NA.83

product name

4-Nitrophenyl valerate, liquid

Assay

≥98% (TLC)

form

liquid

color

faintly yellow to dark yellow

storage temp.

−20°C

SMILES string

CCCCC(=O)Oc1ccc(cc1)N(=O)=O

InChI

1S/C11H13NO4/c1-2-3-4-11(13)16-10-7-5-9(6-8-10)12(14)15/h5-8H,2-4H2,1H3

InChI key

RJQXEHRFVKJLJO-UHFFFAOYSA-N

Application

4-Nitrophenyl valerate has been used as a substrate solution to measure the rate of p-nitrophenol formation using p-nitrophenyl valerate as substrate. It has also been used as a substrate to measure general esterase activity in hepatopancreas extracts.

Biochem/physiol Actions

4-Nitrophenyl valerate acts as a model substrate for carboxylesterase and butyrylcholinesterase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N4377-10G:
N4377-VAR:
N4377-1G:
N4377-BULK:
N4377-5G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lincoln A MacKenzie et al.
Toxicon : official journal of the International Society on Toxinology, 60(3), 406-419 (2012-05-23)
An enzyme capable of hydrolysing pectenotoxins (PTXs) and okadaic acid (OA) esters within the hepatopancreas of the Greenshell™ mussel Perna canaliculus was isolated and characterized. The enzyme was purified by sequential polyethylene glycol fractionation, anion exchange, hydrophobic interaction, gel filtration
Sonja Kübelbeck et al.
Macromolecular bioscience, 18(7), e1800095-e1800095 (2018-06-06)
Herein, the synthesis of enzyme-polymer conjugates is reported. Four different activated polymers (mPEG-aldehyde, mPEG-NHS, maltodextrin-aldehyde, carboxymethyl cellulose aldehyde) are conjugated to the surface of protease, α-amylase, and lipase using two different strategies (reductive amination and alkylation with NHS-activated acid). Although
Brittany N Szafran et al.
Molecules (Basel, Switzerland), 23(12) (2018-12-06)
Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS)-induced inflammation in mice, which may serve as a negative feedback mechanism to increase endocannabinoid levels and reduce inflammation. Increased plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) and decreased fatty acid
Xia Wen et al.
Toxicology, 416, 15-22 (2019-01-28)
Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with dyslipidemia in exposed populations. In
Mikael Skaanning Jørgensen et al.
Microbial cell factories, 13(1), 33-33 (2014-03-08)
The industrially applied filamentous fungus Trichoderma reesei has received substantial interest due to its highly efficient synthesis apparatus of cellulytic enzymes. However, the production of heterologous enzymes in T. reesei still remains low mainly due to lack of tools for
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