Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

N2790

Sigma-Aldrich

Nucleozin

≥98% (HPLC), powder

Synonym(s):

Nucleozin, 1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine, [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
¥16,500
25 MG
¥42,400

¥16,500

Check Cart for Availability
New, lower price on this item!
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
¥16,500
25 MG
¥42,400

About This Item

Empirical Formula (Hill Notation):
C21H19ClN4O4
CAS Number:
341001-38-5
Molecular Weight:
426.85
MDL number:
MFCD01426660
UNSPSC Code:
12352200
PubChem Substance ID:
329818419
NACRES:
NA.77

¥16,500

Check Cart for Availability
New, lower price on this item!
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

Cc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O

InChI

1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3

InChI key

OWXBJAPOSQSWAO-UHFFFAOYSA-N

Application

Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.[1]

Biochem/physiol Actions

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.
Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N2790-VAR:
N2790-IP:
N2790-25MG:
N2790-BULK:
N2790-5MG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000242533
0000230408
044M4608V
083M4604V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Helma Antony et al.
The Analyst, 138(20), 6073-6080 (2013-08-21)
Influenza is a viral pandemic that affects millions of people worldwide. Seasonal variations due to genetic shuffling and antigenic drifts in the influenza viruses have necessitated continual updating of therapeutics. The growing resistance to current influenza drugs has increased demand

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service