Skip to Content
Merck
All Photos(1)

Documents

Safety Information

M9948

Sigma-Aldrich

Mirin

≥98% (HPLC), powder

Synonym(s):

5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H8N2O2S
CAS Number:
299953-00-7
Molecular Weight:
220.25
MDL number:
MFCD05885480
UNSPSC Code:
12352200
PubChem Substance ID:
329818100
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

red to orange

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2

InChI

1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-

InChI key

YBHQCJILTOVLHD-YVMONPNESA-N

Gene Information

human ... MRE11A(4361)

Related Categories

Application

Mirin has been used:
  • as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
  • as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
  • in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Biochem/physiol Actions

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.
Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M9948-IP:
M9948-VAR:
M9948-25MG:
M9948-5MG:
M9948-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability
Edwards TG, et al.
PLoS ONE, 8(10), e75406-e75406 (2013)
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
Ann Liza Piberger et al.
Nature communications, 11(1), 5863-5863 (2020-11-19)
Stalled replication forks can be restarted and repaired by RAD51-mediated homologous recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle. Bulky DNA adducts are important replication-blocking lesions, but it is unknown whether they activate HR
J-Y Wang et al.
Oncogene, 35(13), 1657-1670 (2015-06-23)
DNA repair is critical for the maintenance of genome stability. Upon genotoxic stress, dysregulated DNA repair may induce apoptosis. Translin-associated factor X (TRAX), which was initially identified as a binding partner of Translin, has been implicated in genome stability. However
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service