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M8193

Sigma-Aldrich

MADAM dihydrochloride

Synonym(s):

2-(2′-Amino-4′-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H22Cl2N2S
CAS Number:
411208-45-2
Molecular Weight:
345.33
MDL number:
MFCD07370142
UNSPSC Code:
12352202
PubChem Substance ID:
24724543
NACRES:
NA.77

form

solid

storage condition

desiccated
protect from light
under inert gas

color

white

solubility

H2O: ~18 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CN(C)Cc1ccccc1Sc2ccc(C)cc2N

InChI

1S/C16H20N2S.2ClH/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3;;/h4-10H,11,17H2,1-3H3;2*1H

InChI key

GSBZMNLLLNHKDY-UHFFFAOYSA-N

Biochem/physiol Actions

High affinity ligand for the serotonin transporter SERT

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M8193-BULK:
M8193-VAR:
M8193-5MG:
M8193-25MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sylvie Chalon et al.
The Journal of pharmacology and experimental therapeutics, 304(1), 81-87 (2002-12-20)
Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowing the study of this transporter in vitro and in vivo, we synthesized a new
Patrick Emond et al.
Journal of medicinal chemistry, 45(6), 1253-1258 (2002-03-08)
A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of K(i) values revealed that most of

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