Skip to Content
Merck
All Photos(1)

Documents

Safety Information

M7945

Sigma-Aldrich

Mephetyl tetrazole

≥98% (HPLC), oil

Synonym(s):

1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H22N4O
CAS Number:
916923-10-9
Molecular Weight:
334.41
MDL number:
MFCD11045297
UNSPSC Code:
12352200
PubChem Substance ID:
329818044
NACRES:
NA.77

Assay

≥98% (HPLC)

form

oil

color

pale yellow

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1

InChI

1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3

InChI key

VREPWWBWXVLSEF-UHFFFAOYSA-N

Biochem/physiol Actions

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M7945-BULK:
M7945-VAR:
M7945-25MG:
M7945-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Potassium Channels

We offer many products related to potassium channels for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service