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M6876

Sigma-Aldrich

D-Mannose 6-phosphate disodium salt hydrate

≥97.0% dry basis (enzymatic)

Synonym(s):

Sodium (2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl phosphate

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About This Item

Empirical Formula (Hill Notation):
C6H11Na2O9P · xH2O
CAS Number:
33068-18-7
Molecular Weight:
304.10 (anhydrous basis)
UNSPSC Code:
12352201
PubChem Substance ID:
24897121
NACRES:
NA.25

biological source

wood (birch wood)

Quality Level

300

Assay

≥97.0% dry basis (enzymatic)

form

powder

impurities

≤1.0% total fructose 6-phosphate and glucose 6-phosphate

color

white to off-white

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

cation traces

Na: 13.2-17.0% (dry basis)

storage temp.

−20°C

SMILES string

[Na+].[Na+].[H]O[H].OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O

InChI

1S/C6H13O9P.2Na.H2O/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5+,6?;;;/m1.../s1

InChI key

UUWJZXLTPORJKW-XTAHGNKUSA-L

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General description

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess the phenotyping of primary human microglia. It has also been used in a study to investigate the identification of Anogeissus latifolia Wallich and analyze refined gum ghatti.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

M6876-100MG:4548174008744
M6876-10MG:4548174008751
M6876-BULK:
M6876-VAR:
M6876-1G:4548174008768
M6876-500MG:4548174008775

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jeroen Melief et al.
Glia, 60(10), 1506-1517 (2012-06-29)
Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia from postmortem human brain tissue and studied their immediate ex vivo phenotype and responses to
Yunpeng Liu et al.
The Journal of organic chemistry, 76(21), 8682-8689 (2011-10-01)
Mannose-6-phosphate (M6P) containing N-linked glycans are the essential targeting signals for hydrolases sorting in eukaryotic cells. To facilitate their structural and binding analyses, a highly efficient and convergent method has been developed to prepare complex N-linked glycans with well-defined M6P
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for
Synthesis of mannose-6-phosphate analogues and their utility as angiogenesis regulators.
Véronique Barragan-Montero et al.
ChemMedChem, 6(10), 1771-1774 (2011-07-28)
Wei Cheong Ngeow et al.
Journal of anatomy, 219(5), 638-645 (2011-08-05)
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural
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