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M6403

Sigma-Aldrich

(±)-3,4-Methylenedioxymethamphetamine hydrochloride

Synonym(s):

(±)-MDMA hydrochloride, DL-3,4-Methylenedioxymethamphetamine, DL-MDMA hydrochloride, Ecstasy, XTC hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H15NO2 · HCl
CAS Number:
64057-70-1
Molecular Weight:
229.70
MDL number:
MFCD00079444
UNSPSC Code:
12352116
PubChem Substance ID:
24897006
NACRES:
NA.77

Quality Level

200

drug control

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

SMILES string

Cl[H].CNC(C)Cc1ccc2OCOc2c1

InChI

1S/C11H15NO2.ClH/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10;/h3-4,6,8,12H,5,7H2,1-2H3;1H

InChI key

LUWHVONVCYWRMZ-UHFFFAOYSA-N

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Biochem/physiol Actions

Hallucinogen; releases serotonin and dopamine from axon terminals; selective serotonergic neurotoxin.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H336

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M6403-VAR:
M6403-10MG:
M6403-BULK:
M6403-50MG:
M6403-10MG-PW:
M6403-50MG-PW:
M6403-1G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zahra Nazari et al.
Iranian journal of basic medical sciences, 25(9), 1091-1096 (2022-10-18)
Ecstasy is a popular recreational psychostimulant with side effects on the central nervous system. This study examined the corpus striatum tissue of adult rats that received ecstasy during the embryonic period for histological and molecular studies. Rats were divided into
M M Iravani et al.
Synapse (New York, N.Y.), 36(4), 275-285 (2000-05-20)
We examined the effects of pressure ejected 3, 4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata
M I Colado et al.
British journal of pharmacology, 126(4), 911-924 (1999-04-08)
1. We investigated whether dopamine plays a role in the neurodegeneration of 5-hydroxytryptamine (5-HT) nerve endings occurring in Dark Agouti rat brain after 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration. 2. Haloperidol (2 mg kg(-1) i.p.) injected 5 min prior and 55
G A Ricaurte et al.
Neuropsychobiology, 42(1), 5-10 (2000-06-27)
The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons. Although
A Lavelle et al.
British journal of pharmacology, 128(5), 975-980 (1999-11-11)
1. We have investigated the effects of methylenedioxymethamphetamine (MDMA, 'ecstasy') on peripheral noradrenergic neurotransmission in the rat. 2. In rat atrial slices pre-incubated with [3H]-noradrenaline and in the presence of desipramine (1 micronM) to prevent effects of MDMA on basal
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