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Safety Information

M1695

Sigma-Aldrich

MAZ51

≥98% (HPLC), solid

Synonym(s):

3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O
CAS Number:
163655-37-6
Molecular Weight:
314.38
MDL number:
MFCD04036983
UNSPSC Code:
12352200
PubChem Substance ID:
24724533

Assay

≥98% (HPLC)

form

solid

color

orange

solubility

DMSO: 11 mg/mL

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)c4ccccc14

Biochem/physiol Actions

Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M1695-25MG:
M1695-VAR:
M1695-BULK:
M1695-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
026K4611

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Ji Yoon Lee et al.
Cancer letters, 354(2), 281-289 (2014-08-27)
Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer
Jeffrey Harding et al.
The American journal of pathology, 185(2), 432-445 (2015-01-20)
Granulomatous inflammation is characteristic of many autoimmune and infectious diseases. The lymphatic drainage of these inflammatory sites remains poorly understood, despite an expanding understanding of lymphatic role in inflammation and disease. Here, we show that the lymph vessel growth factor
Jeong Ae Park et al.
PLoS genetics, 11(7), e1005324-e1005324 (2015-07-07)
Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail
Joo-Hee Park et al.
PloS one, 9(9), e109055-e109055 (2014-10-01)
MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape

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