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Safety Information

L1290

Sigma-Aldrich

Lactoferricin B, fragment 4-14 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

bLFC (26-36), bovine lactoferricin

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1 MG
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About This Item

Empirical Formula (Hill Notation):
C70H113N25O13S
Molecular Weight:
1544.87
MDL number:
MFCD04040902
UNSPSC Code:
12352202
NACRES:
NA.32

¥55,000

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Quality Level

200

Assay

≥95% (HPLC)

solubility

H2O: soluble

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell membrane | interferes

storage temp.

−20°C

Amino Acid Sequence

Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly

General description

Chemical structure: peptide

Application

Lactoferricin B, fragment 4-14 trifluoroacetate salt has been used to study effect of lactoferricin on cell proliferation of human colon cancer cells.[1] It has been used in study of ultraviolet light-mediated DNA damage in human colon cancer cells.[2]

Biochem/physiol Actions

Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.
Lactoferricin B also suppresses liver and lung metastasis in murine melanomas and lymphomas. In addition, it causes cell death in human leukemic and carcinoma cell lines.[3] It is effective against Escherichia coli, Salmonella enteritidis, Klebsiella pneumoniae, Proteus vulgaris, Yersinia enterocolitica, Pseudomonas aeruginosa, Campylobacter jejuni, Staphylococcus aureus, Streptococcus mutans, Corynebacterium diphtheriae, Listeria monocytogenes and Clostridium perfringens.[4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L1290-VAR:
L1290-1MG:
L1290-BULK:
L1290-1MG-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCQ9147
SLCQ9150
SLCR6582
0000260173
0000252383

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W Bellamy et al.
The Journal of applied bacteriology, 73(6), 472-479 (1992-12-01)
A physiologically diverse range of Gram-positive and Gram-negative bacteria was found to be susceptible to inhibition and inactivation by lactoferricin B, a peptide produced by gastric pepsin digestion of bovine lactoferrin. The list of susceptible organisms includes Escherichia coli, Salmonella
C Freiburghaus et al.
Journal of dairy science, 92(6), 2477-2484 (2009-05-19)
Food components modify the risk of cancer at a large number of sites but the mechanism of action is unknown. In the present investigation, we studied the effect of the peptide lactoferricin derived from bovine milk lactoferrin on human colon
Liv Tone Eliassen et al.
International journal of cancer, 119(3), 493-500 (2006-03-31)
Antimicrobial peptides have been shown to exert cytotoxic activity towards cancer cells through their ability to interact with negatively charged cell membranes. In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human
C Freiburghaus et al.
Journal of dairy science, 95(10), 5552-5560 (2012-08-21)
Treatment of Caco-2 cells with the peptide lactoferricin(4-14), results in reduction of the growth rate by prolongation of the S phase of the cell cycle. Lactoferricin(1-25) is formed in the gut by cleavage from lactoferrin and the bioactive amino acids

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