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L0881

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

lyophilized powder, Affinity-purified

Synonym(s):

PNA, Peanut agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

form

lyophilized powder

Quality Level

200

potency

<0.1 μg per mL agglutination activity

quality

Affinity-purified

impurities

salt, free

storage temp.

−20°C

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General description

Lectin from Arachis hypogaea (peanut) is a homotetrameric protein of 110 kDa.

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • to detect Thomson-Friedenreich antigen
  • as a component in PBS to study its effects on cell viability
  • to study its ability to block the binding site

Biochem/physiol Actions

Lectin from Arachis hypogaea (peanut) possess specificity towards β -D-Gal(1-3)-D-galNAc residue of Thomson − Friedenreich antigen. It is the most widely used diagnostic and prognostic marker for many squamous cell carcinomas.
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Analysis Note

Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of neuraminidase treated human blood group O erythrocytes after 1 hr incubation at 25 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L0881-25MG-PW:
L0881-VAR:
L0881-5MG:
L0881-25MG:
L0881-5MG-PW:
L0881-2MG:
L0881-1MG:
L0881-10MG-PW:
L0881-10MG:
L0881-BULK:
I-61409:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Towler MJ and Weathers PJ
Journal of Biotechnology, 101(2), 147-155 (2003)
In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell-endothelial cell interaction
Gassmann P
BMC Cancer, 10(1), 177-177 (2010)
In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death
Mukhopadhyay S, et al.
Food And Chemical Toxicology, 64, 369-377 (2014)
Lectin binding and effects in culture on human cancer and non-cancer cell lines: examination of issues of interest in drug design strategies
Petrossian K, et al.
Acta Histochemica, 109(6), 491-500 (2007)
Peter Gassmann et al.
BMC cancer, 10, 177-177 (2010-05-04)
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