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J4205

Sigma-Aldrich

JK184

≥98% (HPLC), powder

Synonym(s):

N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

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About This Item

Empirical Formula (Hill Notation):
C19H18N4OS
CAS Number:
315703-52-7
Molecular Weight:
350.44
UNSPSC Code:
51111800
PubChem Substance ID:
329815733
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

CCOc1ccc(Cc2nc(cs2)-c3c(C)nc4ccccn34)cc1

InChI

1S/C20H19N3OS/c1-3-24-16-9-7-15(8-10-16)12-19-22-17(13-25-19)20-14(2)21-18-6-4-5-11-23(18)20/h4-11,13H,3,12H2,1-2H3

InChI key

CBKFVRMNQUKWPX-UHFFFAOYSA-N

Biochem/physiol Actions

JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

J4205-VAR:
J4205-BULK:
J4205-25MG:
J4205-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Helen O Oladapo et al.
Cancer letters, 411, 136-149 (2017-10-03)
Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing distinct

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