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J4144

Sigma-Aldrich

Jo-1 human

recombinant, expressed in E. coli, solution

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About This Item

MDL number:
MFCD03457272
UNSPSC Code:
12352204
NACRES:
NA.83

recombinant

expressed in E. coli

Quality Level

200

form

solution

mol wt

55 kDa by SDS-PAGE

UniProt accession no.

P12081

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HARS(3035)

General description

Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.

Biochem/physiol Actions

The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.
Used in the immunoassay for antibodies to Jo-1.

Physical form

Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

J4144-VAR:
J4144-BULK:
J4144-100UG:
J4144-100UG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Nishikai et al.
British journal of rheumatology, 37(4), 357-361 (1998-06-10)
We evaluated an enzyme-linked immunosorbent assay (ELISA) for detecting anti-Jo-1 antibodies in patients with polymyositis (PM) or dermatomyositis (DM) by use of the recombinant fusion protein Jo-1. Sera from 64 patients with PM or DM, from 80 patients with other
Luis M Molinos-Albert et al.
Nature communications, 13(1), 1944-1944 (2022-04-13)
HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of

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